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Progesterone
Hormone Replacement Therapy
Progesterone prepares the endometrium for the potential of pregnancy after ovulation. It triggers the lining to thicken to accept a fertilized egg. It also prohibits the muscle contractions in the uterus that would cause the body to reject an egg.
Oral Administration : The usual dose is from 200-300mg of progesterone per day once daily or in two divided doses , one in the morning , one at night. It is recommended to use the capsule at intervals of one hour before or after meals . The evening dose / once daily is preferably taken at night at the time of going bed. Vaginal Administration : The dosage recommended is 400 to 600mg per day starting with the day of injection of hCG up to the 12th week of pregnancy. Each capsule should be deeply inserted into the vagina. Always consult your doctor or pharmacist for dose adjustments.
Diziness , headache , fatigue , emotional lability , abdominal pain / distension , musculoskeletal pain, early or rarely delayed menstruation. soreness , diarrhoea , flatulence with rectal route.
CYP450-3A4 such as barbiturates, anti-epileptic agents (phenytoin, carbamazepine), rifampicin, phenylbutazone, bromcriptine, spironolactone, griseofulvin, some antibiotics (ampicillins, tetracyclines) and also herbal products containing St. John’s wort, (Hypericum perforatum) , Ketokonazole and other inhibitors of CYP450-3A4 such as ritonavir and nelfinavir , ciclosporin , Aminoglutethimide , coumarins , anti-diabetic drugs , diazepam , tizanidine , terbinafine .
It is used in various female reproductive health conditions associated with low progesterone.
Known hypersensitivity to the active substances, soybean lecithin, peanut or to any of the excipients listed . Known or Past or suspected breast cancer , Known or suspected estrogen-dependent malignant tumours (e.g genital tract carcinoma) , Undiagnosed genital bleeding.
Before initiating or reinstituting HRT, a complete personal and family medical history should be taken.
For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually, and HRT should only be continued as long as the benefit outweighs the risk.
HRT is associated with a 1.3-3 fold risk of developing venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism.
Women already on chronic anticoagulant treatment require careful consideration of the benefit-risk of use of HRT.
Always consult your physician before using any medicine.
Store in a refrigerator (2°C–8°C). Do not Freeze .
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