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Estradiol Valerate
Hormone Replacement Therapy
The active ingredient estradiol valerate, a prodrug of the synthetic 17ß-estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in menopausal women, and alleviates menopausal symptoms. Oestrogens prevent bone loss following menopause or ovariectomy. Ovulation is not inhibited during the use of Progynova, and the endogenous production of hormones is hardly affected.
Adults : Climacteric syndrome : 1mg or 2mg daily . For maintenance , use lowest effective dose . Prophylaxis of osteoporosis : 2mg daily . In women with an intact uterus and a progesteron for 12 days of each day . Children : Not applicable . OR As directed by your physician .
Nausea , vomiting , weight gain , breast tenderness & enlargement , withdrawal bleeding , sodium retention with oedema , liver function disorders , jaundice , rashes , chloasma , headache . Endometrial carcinoma in post-menopausal women .
Diuretics , antihypertensives , liver enzymes inducing drugs .
It provides hormone replacement therapy (HRT) for the treatment of menopausal complaints after the cessation of monthly bleeding, or after surgical removal of the ovaries (oophorectomy). Also used in prophylaxis of osteoporosis . It is only intended for short term use.
Do not take it if you are hypersensitive to any of the ingredients in the list.
If you have a tendency to develop blotchy brown patches (chloasma) on the face you should avoid exposure to the sun or ultraviolet light whilst using Progynova.
For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risk and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk
The risk of blood clots in the veins (also called deep vein thrombosis, or DVT) is about 1.3 to 3–times higher in HRT users than non-users, especially during the first year of taking it.
HRT is not recommended for women who have heart disease, or have had heart disease recently. If you have ever had heart disease, talk to your doctor to see if you should be taking HRT.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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