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Estradiol Valerate , Cyproterone Acetate
Hormone Replacement Therapy
Estradiol is a steroid hormone and, therefore, can easily cross the cell membrane. Estrone binds to its specific intracellular receptor and regulates DNA transcription for protein formation. The mechanism of action of cyproterone involves blocking the androgen receptor. Cyproterone is an antiandrogen. It suppresses the actions of testosterone (and its metabolite dihydrotestosterone) on tissues.
Adults : Patients with amenorrhoea (rule out pregnancy beforehand) and postmenopausal women can start taking the tablets 1 per day over 21 days on any day they like. Children : Not applicable .
A feeling of tension in the breasts, intermenstrual bleeding, gastric complaints, nausea and changes of body weight and libido occur. Oedema, headache and depressive moods occur.
Various substances (eg barbiturates, phenylbutazone, hydantoins, rifampicin) accelerate the metabolism of steroid hormones (possible impairment of effect); reduced substance levels have also been observed on concurrent use of some antibiotics (eg ampicillin) as a result of alteration of the intestinal flora.
It is indicated in patients (with intact uteri) suffering from climacteric symptomatology. This therapy may be used as an adjunct in preventing osteoporosis in postmenopausal women.
Pregnancy, lactation, severe disturbances of liver function, jaundice or persistent itching during a previous pregnancy, previous or existing tumours of the liver, uterus, ovaries or breast or a suspicion of such tumours, endometriosis, existing or previous thromboembolic processes, severe diabetes mellitus with vascular changes, sickle-cell anaemia, disturbances of lipometabolism,
Strict medical supervision is necessary in patients with diabetes, hypertension, varicose veins, a history of phlebitis, otosclerosis, multiple sclerosis, epilepsy, porphyria, tetany, chorea minor.
The requirement for antidiabetics or insulin can change as a result of an effect on glucose tolerance.
Before it is used, a thorough general medical (including measurement of blood pressure, analysis of urine for sugar, if applicable performance of special liver diagnostics as well) and gynaecological (including the breast and a cytological smear of the cervix and portio) examination should be performed .
Tablet-taking is always started from the blister marked Start and continued daily in the direction of thearrows until all 28 tablets have been taken.
Always consult your physician before using any medicine.
Store this medicine at room temperature, away from direct light and heat.
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